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February 2, 1976

Hematin Treatment of Acute Porphyria: Early Remission of an Almost Fatal Relapse

Author Affiliations

From the Department of Medicine, Maricopa County General Hospital, Phoenix, Ariz (Dr Peterson), and the University of Minnesota Medical Research Unit, Abbott-Northwestern Hospital, Minneapolis (Mss Bossenmaier and Cardinal, Dr Watson). Dr Peterson is now practicing in Ontario, Ore.

JAMA. 1976;235(5):520-522. doi:10.1001/jama.1976.03260310034018

Intravenous infusions of hematin in a young woman with acute porphyria in profound relapse was followed within 48 hours by remission of symptoms and rapid recovery. From a state of severe central and peripheral nervous-system involvement, the patient recovered so completely that she was able to leave the hospital in less than a month, with only a residual weakness of her arms. Serial studies of serum and urinary levels of porphyrin precursors and serum level of hematin provided highly important information about the effect of hematin on acute porphyria.

(JAMA 235:520-522, 1976)