Two children presenting typical clinical features of the hemolytic-uremic syndrome had a positive direct Coombs test that remained positive throughout the illness. It is probable that an upper respiratory tract infection precipitated an antigen-antibody reaction that caused the autoimmune hemolytic anemia and immune-complex glomerulonephritis.
(JAMA 235:522-523, 1976)
Ferris FZ, Zeis PM. Coombs-Positive Hemolytic Uremic Syndrome. JAMA. 1976;235(5):522–523. doi:10.1001/jama.1976.03260310036019
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