Two patients with nontraumatic bladder rupture and intraperitoneal extravasation of urine were found to have an elevation of blood urea nitrogen (BUN) content disproportionate to the normal or mildly elevated serum creatinine value. In the absence of other causes for this disproportion, and supported by observations on BUN and creatinine removal in peritoneal dialysis, it is suggested that in azotemic subjects a ratio of BUN to creatinine level far in excess of the mean figure of 10.8 to 1 may occur as a result of intraperitoneal extravasation of urine.
Sullivan MJ, Lackner LH, Banowsky LHW. Intraperitoneal Extravasation of Urine: BUN/Serum Creatinine Disproportion. JAMA. 1972;221(5):491–492. doi:10.1001/jama.1972.03200180033008
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