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February 16, 1976

Scleroderma and Hyperthyroidism: Report of a Case

Author Affiliations

From the Department of Internal Medicine, Isfahan University, Isfahan, Iran.

JAMA. 1976;235(7):752-753. doi:10.1001/jama.1976.03260330046025

SCLERODERMA has been reported in association with Hashimoto thyroiditis, Sjögren syndrome, congenital hypergammaglobulinemia, myasthenia gravis, mycosis fungoides, muscular dystrophy, and urticaria pigmentosa; and hyperthyroidism in association with thyroid acropachy, vitiligo, pretibial myxedema, alopecia areata, and melanoderma.1-3 Even scleroderma-like thickening of extremities has been reported as a skin manifestation of hyperthyroidism,4 but, to the best of our knowledge, scleroderma has not been reported in direct association with hyperthyroidism.

Report of a Case  A 40-year-old woman was admitted to the Khorshid Medical Center, affiliated with Isfahan University, in September 1973, complaining of palpitation, tremor of hands, dysphagia, and pain in the extremities, all of six months' duration. History disclosed pain in the joints when exposed to cold, and amenorrhea for 18 months prior to admission.On physical examination, the pulse rate was 110 beats per minute; and blood pressure, 120/75 mm Hg. Temperature was normal.The patient had exophthalmos, with