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February 23, 1976

Re: Increased Virus Shedding With Aspirin Treatment of Rhinovirus Infection

Author Affiliations

Tulane University School of Medicine New Orleans

JAMA. 1976;235(8):801. doi:10.1001/jama.1976.03260340011003

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To the Editor.—  In the recent report by Stanley et al (231:1248, 1975) rhinovirus types 21 or 25 were recovered more often from infected volunteers receiving 0.6 gm of aspirin three times daily for five days than from placebo-treated and also infected controls. Because of this, we report the following.Rhinovirus, type 1A (third passage in WI-38 cells; 50% tissue culture infective dose, 104.5/ml) was inoculated into nonimmune young adults, 0.75 ml in each nostril. Pharyngeal washings for virus isolation were obtained on days 1, 2, and 3. When symptoms of an upper respiratory tract illness began, volunteers were given aspirin or placebo, 0.6 gm four times daily. In those receiving medication from day 1, there were 7 of 18 rhinovirus-positive specimens in the aspirin group and 9 of 18 in the placebo group on days 2 and 3. When treatment was begun on day 2, five of