Seventy-two volunteer blood donors who had hepatitis B surface antibody (anti-HBs) were studied and compared with 115 carriers of hepatitis B surface antigen (HBsAg). Anti-HBs-positive donors gave a history of greater possible exposure to hepatitis B virus, there was a lower male-female ratio, and they had a much lower frequency of abnormal hepatic function test results. Those who were positive by counterimmunoelectrophoresis (CIEP), which indicated a high titer of antibody (>1:2,000 as measured by passive hemagglutination assay [PHA]), also had an ethnic origin similar to that of the donor panel, ie, predominantly Canadian and northern European. The HBsAg carriers, on the other hand, had a high frequency of origin from Mediterranean and Far Eastern countries. Low-antibody-titer (positive PHA but negative CIEP) donors had ethnic origins that more closely approximated those of HBsAg carriers.
(JAMA 235:1014-1017, 1976)
Sinclair JC, Feinman SV, Wrobel DM, Berris B. Hepatitis B Surface Antigen and Antibody in Asymptomatic Blood Donors. JAMA. 1976;235(10):1014–1017. doi:10.1001/jama.1976.03260360016017
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