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March 15, 1976

Galactorrhea and Antipsychotic Agents

Author Affiliations

Silver Spring, Md

JAMA. 1976;235(11):1107. doi:10.1001/jama.1976.03260370017011

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To the Editor.—  In reading LETTERS TO THE EDITOR (234:913, 1975), I was most surprised at the comments of Drs Masco and Leis concerning galactorrhea and antipsychotic agents. The wish of a physician to avoid galactorrhea in a patient requiring an antipsychotic agent is perfectly reasonable from the clinical point of view. The sudden onset of galactorrhea in a psychotic patient can add appreciably to that patient's anxiety and confusion; it may cause a significant alteration of the patient's fantasy life and body image. It is therefore reasonable to avoid the symptom if possible.Frequently, galactorrhea develops in response to a specific neuroleptic or family of neuroleptics. Thus, the symptom can often be avoided by simply switching to a different family of neuroleptic drugs. Cessation of galactorrhea therapy while maintaining a therapeutic dosage of the antipsychotic medication is more desirable than reassuring the patient with the galactorrhea or discontinuing use of