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March 24, 1969

Subacute Sclerosing Panencephalitis: A Multidisciplinary Study of Eight Cases

Author Affiliations

From the departments of neurology (Dr. Lemmi) and biochemistry (Dr. Ragland), the Section of Pediatric Neurology (Drs. Jabbour and Duenas), and the Division of Neuropathology (Dr. Garcia), University of Tennessee Medical Units, Memphis; and the Section on Infectious Disease, Perinatal Research Branch, National Institute of Neurological Diseases and Blindness, Bethesda, Md (Dr. Sever).

JAMA. 1969;207(12):2248-2254. doi:10.1001/jama.1969.03150250078007

Clinical, electroencephalographic, and other laboratory features and subacute sclerosing panencephalitis (SSPE) were studied in eight patients by the same group of investigators. The relatively high frequency of the disease within a small geographical area in a short period of time suggests that SSPE may be unusually common in the vicinity of Memphis. The delineation of four clinical stages of the disease, markedly elevated measles antibody titers in serum and cerebrospinal fluid, ultrastructural observation of intranuclear and intracytoplasmic inclusions in neurons and neuroglia in three patients, and alteration of serum and CSF immunoglobulins indicate that the measles myxovirus may be the etiological agent in these patients.