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March 29, 1976

Listeria Infection in Renal Transplant Recipients

Author Affiliations

Boston City Hospital Boston University School of Medicine

JAMA. 1976;235(13):1326. doi:10.1001/jama.1976.03260390012009

To the Editor.—  In his article (234:842, 1975), Isiadinso stated: "To our knowledge, there have been no other reports, in the English literature, of Listeria infection complicating renal transplantation"; however, this association has been well documented.1-5 Listeriosis has also occurred sporadically in several other renal, as well as cardiac, transplantation centers.The occurrence of six cases of listeriosis in a nine-month period in their renal transplantation unit should have been the emphasis of the report. This constitutes a cluster and raises the following questions: Did the organisms have the same serotype? What epidemiologic studies were undertaken to attempt to explain this outbreak?We reported a cluster of eight cases of listeriosis in a 15-month period in immunosuppressed patients. Four of the patients were renal transplant recipients.5 The occurrence of a cluster of cases caused by an opportunistic agent such as Listeria is the ideal setting to study the