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April 12, 1976

Clinical Problems With Drugs

Author Affiliations

Medical Center of Western Massachusetts Springfield

JAMA. 1976;235(15):1619. doi:10.1001/jama.1976.03260410069036

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


A rapidly advancing medical technology, coupled with a blossoming pharmaceutical industry, created an increasing number of complex drugs. Despite their benefits, these have produced a rapidly growing number of adverse reactions that result in a large number of hospital admissions, major disability, and even death. In this relatively brief, easily read monograph, the authors systematically deal with adverse drug reactions.

Proceeding from an initial chapter on perspectives on drug-induced diseases, the development of a formulary, and modes of regulating drug use, to an epidemiologic view of the problems of drugs for hospitalized patients, they demonstrate how adverse reactions occur more commonly as the number and duration of use increases. The authors stress the limitations of physician education and the need to increase awareness of potential toxicity. Two chapters analyze some mechanisms of toxicity and the biologic determinants of adverse reactions in normal and in ill individuals.

A very simple tabular