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April 26, 1976

Lymphogranuloma Venereum A Cause of Cervical Lymphadenopathy

Author Affiliations

From the departments of medicine (Division of Infectious Diseases) (Drs Thorsteinsson and Musher) and pathology (Drs Min and Gyorkey), Baylor College of Medicine and the Veterans Administration Hospital, Houston.

JAMA. 1976;235(17):1882. doi:10.1001/jama.1976.03260430052029

CERVICAL lymphadenopathy is a relatively common clinical problem. Differential diagnosis includes hematological, lymphoreticular, or metastatic malignancies, mycobacterial, bacterial, viral, or rickettsial infections, and diseases of unknown etiology such as sarcoidosis and catscratch fever. In this report, we describe a patient whose cervical lymphadenopathy was the presenting manifestation of lymphogranuloma venereum infection.

Report of a Case  A 31-year-old graduate student was admitted to the Houston Veterans Administration Hospital because of cervical lymphadenopathy. In the two months before admission, he noted anorexia, easy fatigability, and a 6.5-kg weight loss. Eight days before admission, he began to have a low-grade fever associated with enlarging lymph nodes on the left side of his neck. He denied recent infections of the teeth or tongue, penile lesions, or urethral discharge. Former medical history was unremarkable except for one year of prophylactic isoniazid therapy in 1969 for a positive tuberculin skin test. He admitted to moderate use