The involvement of the joints that may follow immunization with live rubella virus vaccines is strongly age-related. The present policy of extending vaccination to postpubescent girls and adult women requires precise definition of the reactions likely to be encountered by physicians in routine use of the vaccine. Six hundred fifty-three females, eight months to 41 years of age, who were initially without rubella antibody were given duck cell attenuated HPV-77 rubella virus vaccine. Reactions in the joints (arthritis or arthralgia or both) were not seen in children under 12 years of age, were seen infrequently in the 12- to 25-year-old age group (7.5%), and were encountered with high frequency (58.3%) in women who were 26 to 41 years old. Reactions were transient, self-limited, of short duration, and mild in all but a few older women.
Weibel RE, Stokes J, Buynak EB, Hilleman MR. Influence of Age on Clinical Response to HPV-77 Duck Rubella Vaccine. JAMA. 1972;222(7):805–807. doi:10.1001/jama.1972.03210070037010
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