A 52-year-old woman complained of epigastric pain, early satiety, post-prandial vomiting, and weight loss of six months' duration. An upper gastrointestinal roentgenographic series was performed (Fig 1 and 2). Two years earlier she had undergone abdominal surgery for a related illness.
Crohn disease of the stomach and duodenum.
Figures 1A and B demonstrate rigidity, narrowing, and irregularity of the antrum, pylorus, and duodenum. A "cobblestone" or "string of pearls" appearance of the mucosa in the body of the stomach is clearly seen in Fig 1C and D and 2. Figure 3 shows pseudopolypoid nodulation of the mucosa in the resected specimen of the stomach that closely parallels with the roentgenographic pattern shown in Fig 1C and D. Figure 4 illustrates the histologic appearance, showing foci of chronic inflammatory reaction in the submucosa. Granulomas are easily identified and contain many giant cells. No central caseation nor acid-fast bacilli
Ansari A, Anderson Q, Hoppes E, Henrikson E. Gastroduodenal Involvement, With Pain, Vomiting, and Weight Loss. JAMA. 1976;235(18):2013–2014. doi:10.1001/jama.1976.03260440065034
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