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November 20, 1972

The Physiology of the Cerebral Circulation

JAMA. 1972;222(8):1063-1064. doi:10.1001/jama.1972.03210080143040

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Purves has put between covers an extensive consideration of the physiology of the cerebral circulation. He initiates it with a brief consideration of cerebral vascular anatomy, with special emphasis on the microcirculation followed by a detailed review of literature on the innervation of the cerebral vessels. He then addresses himself to the topic at hand and gives a detailed analysis of the systemic and local factors which affect cerebral blood flow. There is an extensive discussion of autoregulation and of experimental approaches to the study of the cerebral circulation. He summarizes the data relating to regulation of cerebral flow by changes in blood gases, pH, reflex responses, and cerebral metabolism and concludes with a consideration of pharmacologic agents which affect cerebral vasomotor tone.

The most important part of this book may be its 1,200 or so references which may turn this monograph into a source book, because it far surpasses