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January 1, 1973

Vancomycin-Streptomycin Synergism in Enterococcal Endocarditis

Author Affiliations

From the Samuel J. Sackett Research Laboratories and the Infectious Diseases—Hypersensitivity Section, Department of Medicine, Northwestern University—McGaw Medical Center (Drs. Paterson and Westenfelder and Mrs. Carlson) and the Northwestern Memorial Hospital, Wesley Pavilion (Dr. Reisberg), Chicago. Dr. Westenfelder is now with Evanston (Ill) Hospital.

JAMA. 1973;223(1):37-40. doi:10.1001/jama.1973.03220010023005

On rare occasion a patient with enterococcal (group D streptococcal) endocarditis will exhibit life-threatening penicillin allergy. The selection of vancomycin hydrochloride and streptomycin as alternate therapy to penicillin-streptomycin under such circumstances is supported by a patient here reported who was cured of enterococcal endocarditis after being treated with vancomycin-streptomycin. In addition, studies upon 18 enterococcal isolates confirm previously reported investigations which indicate that vancomycin and streptomycin in combination exert a synergistic action against a substantial percentage of enterococcal isolates in vitro.