In a community outbreak of hepatitis A (person-to-person transmission) the efficacy of immune serum globulin prophylaxis among patients'family members was between 87% and 98%. Immune serum globulin efficacy was determined by means of a formula used previously to measure live-virus vaccine efficacy in epidemics.
Landrigan PJ, Huber DH, Murphy GD, Creech WB, Bryan JA. The Protective Efficacy of Immune Serum Globulin in Hepatitis A: A Statistical Approach. JAMA. 1973;223(1):74–75. doi:10.1001/jama.1973.03220010060018
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