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January 1, 1973

The Protective Efficacy of Immune Serum Globulin in Hepatitis A: A Statistical Approach

Author Affiliations

From the Epidemiology Program, Center for Disease Control, Health Services and Mental Health Administration, Public Health Service, Department of Health, Education, and Welfare, Atlanta.

JAMA. 1973;223(1):74-75. doi:10.1001/jama.1973.03220010060018

In a community outbreak of hepatitis A (person-to-person transmission) the efficacy of immune serum globulin prophylaxis among patients'family members was between 87% and 98%. Immune serum globulin efficacy was determined by means of a formula used previously to measure live-virus vaccine efficacy in epidemics.