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January 1, 1973

Methadone Relatives And Substitutes

Author Affiliations

State University of New York Stony Brook, LI

JAMA. 1973;223(1):80. doi:10.1001/jama.1973.03220010066028

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To the Editor.—  The report by Jaffe et al (222:437, 1972) is a careful study of methadyl acetate and methadone hydrochloride. Despite the apparent safety of methadyl acetate and its therapeutic equivalence three times a week for methadone daily, the authors choose to caution the reader with the warning, "however, in spite of these potential advantages, the unusual pharmacological actions of methadyl acetate could represent potential hazards."In our studies of a related compound, levomethadyl acetate (220:811, 1972), we were encouraged by our findings that levomethadyl administered three times a week was equivalent to methadone daily in safety, efficacy, and in our physiologic measures. We encouraged further trial of this compound, noting the early reports of some difficulties with methadyl acetate. We have since repeated our study of levomethadyl and affirmed its duration of action and safety. We believe that this compound deserves more extensive clinical trials.The public effort,