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June 21, 1976

Advances in Neurology, vol 13: Current Reviews

Author Affiliations

Veterans Administration Hospital Nashville, Tenn

JAMA. 1976;235(25):2771. doi:10.1001/jama.1976.03260510059037

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In this book are reviewed selected research areas that border basic and clinical neurology. Of special interest is the chapter by Walker and Weiss, predicting that the next decade will see advances in the chemotherapy of brain malignancies to rival recent improvements in the treatment of leukemia. The authors emphasize that clinical studies must be based on animal experimentation and basic pharmacological principles.

A review of nutritional deprivation shows that in animals, the earlier the deprivation, the more permanent the behavioral effects. Many developing countries are crippled by a vicious circle of poverty, producing poor nutrition and incomplete mental development, which intensifies poverty, worsening the nutritional deprivation, and so on. An exhaustive review of the effects of synaptically active agents on seizure frequency plods through voluminous animal studies and uncontrolled clinical observations. Great variation, from model to model in experiments, and from case to case clinically obscures an overall tendency