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January 8, 1973

Multiple Sclerosis: Immunology, Virology, and Ultrastructure

JAMA. 1973;223(2):198. doi:10.1001/jama.1973.03220020064039

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


Despite tantalizing immunologic and epidemiologic clues, real progress in understanding multiple sclerosis eludes us. Many American research workers gathered at a California ranch in February 1972 to consider some recent research results concerning multiple sclerosis and its animal models. This book reproduces in typescript form the invited technical papers and the even more technical discussions. Typescript printing techniques allow rapid publication but produce a page with uneven righthand margins, which is difficult to read. Figures and tables are gathered at the end of each chapter rather than interspersed throughout. The rush to press results in many typographical and grammatical errors. These contributions are so unpolished that the reader may get the feeling that he is reading a typed manuscript from a multiple sclerosis research worker.

Several separate lines of research endeavor are reviewed in this book. Epidemiologic studies suggest that multiple sclerosis is acquired in childhood or adolescence and several