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January 22, 1973

Tetracycline and BUN Level

Author Affiliations

Leiden University, Netherlands

JAMA. 1973;223(4):441. doi:10.1001/jama.1973.03220040055023

To the Editor. —  With interest we read Jick and Slone's report from the Boston Collaborative Drug Surveillance Program on tetracycline and drug-attributed rises in blood urea nitrogen (BUN) level.1We did a pilot study during the winter of 1971 to 1972 in eight ambulant patients with chronic bronchitis; six of them showed a rise in BUN level to abnormal values during treatment with tetracycline in four daily doses of 250 mg. Two patients had pathological BUN values even before treatment (Figure). Most of our observations were similar to those of Jick and Slone. However, in our small series, not only patients with a combined treatment of tetracycline and diuretics showed a rise in BUN level, but also two out of four patients without diuretic therapy. Careful examination and control of renal functions in our patients showed no disturbances of renal functions; in fact, creatinine clearance remained normal in