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July 19, 1976

Mucocutaneous Lymph Node Syndrome

JAMA. 1976;236(3):292. doi:10.1001/jama.1976.03270030046030

In 1974, Kawasaki et al1 reported for the first time in a US medical journal what appears to be a new disease, tentatively called mucocutaneous lymph node syndrome. The first report on mucocutaneous lymph node syndrome had been made in 1967 by Kawasaki,2 whose experience at that time was based on study of 50 cases. Since then, Kawasaki and his colleagues1 observed that more than 6,000 cases have been reported in Japan as of 1973. One to two percent of patients reported had died suddenly of cardiac failure. Search for a causative agent has been unrewarding, except that rickettsia-like bodies were found by electron microscopy in some biopsy specimens from the skin and lymph nodes of patients. The principal symptoms can be tabulated in modified form from the report by Kawasaki et al.

In the current issue of American Journal of Diseases of Children, Melish et al