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February 26, 1973

Albright Syndrome And Leukemia

JAMA. 1973;223(9):1041. doi:10.1001/jama.1973.03220090061020

To the Editor.—  Isolated reports of Albright syndrome have appeared in the literature since his initial description of a disease characterized by fibrous dysplasia of bone, skin pigmentation, and precocious puberty in females.1 This report describes a patient who demonstrated the features of both Albright syndrome and erythroleukemia, a coexistence not previously reported.

Report of a Case.—  A 65-year-old mother of five had fragile bones since childhood with multiple fractures of the right femur, pigmentation over the buttocks, onset of menarche, and secondary sexual characteristics at the age of 7 years. In March 1971, the patient noted fatigue and was found to have the following peripheral blood values: hemoglobin, 9.4 gm/100 ml; white blood cell (WBC) count, 93,600/cu mm; and a differential count of 97% blast cells. Bone marrow aspiration suggested acute leukemia, type unspecified. Over the ensuing six weeks, the patient was treated with a variety of agents