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August 9, 1976

Myositis Ossificans: A Problem of Terminology-Reply

Author Affiliations

University of Utah Medical Center Salt Lake City

JAMA. 1976;236(6):563. doi:10.1001/jama.1976.03270060017017

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In Reply.—  Dr Berrol has suggested that the nontraumatic form of ossification seen in the muscles of healthy individuals be classified as heterotopic ossification. While the etiology and pathogenesis of the entity are unknown, the pathogenesis of the classic forms of myositis ossificans is also unclear. We agree that the term "myositis" implies inflammation as the cause, yet inflammation has not been shown to be a constant factor even in the other well-established forms of myositis ossificans. The role of inflammation in this condition has been poorly defined. While the general term "myositis ossificans" may not be scientifically accurate, it is currently a well-accepted description for ossification occurring within skeletal muscle irrespective of cause. Until the pathogenesis of the various types of myositis ossificans is better understood, we believe that lesions that behave clinically similarly to and have the same histologic and roentgenographic appearance of myositis ossificans should still be