An intensive study of the family history of cancer in 4,515 patients screened consecutively by a multiphasic mobile cancer detection unit showed, after age correction, that cancer had developed in 8.9% of the probands when there was one cancer in a single first-degree relative, 16.2% had cancer with two family members affected, and 27.4% had cancer when three or more family members had been affected. This constituted a significant correlation between family and personal histories of cancer in these patients. Extrapolation to the United States population with cancer-control implications are given.
(JAMA 236:582-584, 1976)
Lynch HT, Brodkey FD, Lynch P, et al. Familial Risk and Cancer Control. JAMA. 1976;236(6):582–584. doi:10.1001/jama.1976.03270060032023
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