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April 23, 1973

Medical News

JAMA. 1973;224(4):455-464. doi:10.1001/jama.1973.03220170003002

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Isolation of cystic fibrosis factor may lead to test for carriers  A factor has been isolated from the serum of cystic fibrosis patients that may lead not only to a diagnostic test for carriers but also to early detection of the disease state.Investigators at the University of Texas Medical Branch, Galveston, reported isolation of the factor at the Sixth International Cystic Fibrosis Congress in Washington, DC. At the same meeting, other investigators engaged in similar studies suggested that the primary defect in cystic fibrosis probably involves an enzyme that normally breaks down this serum factor.Barbara H. Bowman, PhD, reported isolating the protein in fibroblast cultures from 15 of 18 cystic fibrosis patients and eight of ten cystic fibrosis carriers.The existence of a so-called cystic fibrosis factor has been known for several years, but the factor had never before been isolated. The factor has been found to