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September 20, 1976

Immunological Impairment and Susceptibility to Infection After Splenectomy

Author Affiliations

From the Thorndike Laboratory, Beth Israel Hospital, and the Department of Medicine, Harvard Medical School, Boston.

JAMA. 1976;236(12):1376-1377. doi:10.1001/jama.1976.03270130038024

Asplenic patients or those who have undergone splenectomy are prone to overwhelming and often fatal sepsis, which is sometimes associated with disseminated intravascular coagulopathies. Although several pathogens are involved, the most common organism found in these subjects is the pneumococcus, and the infections respond poorly to antibiotic therapy.

(JAMA 236:1376-1377, 1976)