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October 4, 1976

Primary and Secondary Hypothyroidism in Nasopharyngeal Carcinoma

Author Affiliations

From the Metabolism Section, Medical Service, Veterans Administration Hospital, and the Department of Medicine, University of California Hospitals, San Francisco.

JAMA. 1976;236(14):1591-1593. doi:10.1001/jama.1976.03270150025024

We investigated the thyroid and pituitary functions of six of the seven patients with nasopharyngeal carcinoma who had been previously treated with external radiation, and who were seen at the San Francisco Veterans Administration Hospital within a recent 18-month period. Two patients had primary hypothyroidism, and four had secondary hypothyroidism. These findings suggest that thyroid and pituitary abnormalities are frequent complications of both nasopharyngeal carcinoma and its treatment.

(JAMA 236:1591-1593, 1976)