[Skip to Content]
[Skip to Content Landing]
June 11, 1973

Serum Chemistry in the Anxiety States: Albumin and Urea Changes

JAMA. 1973;224(11):1532. doi:10.1001/jama.1973.03220250054026

To the Editor.—  A recent EDITORIAL, "Genetics and Schizophrenia" (223: 1382, 1973) by Dr. Wender, stresses the need for biochemical research in the psychoses. Fairly comprehensive and statistically significant correlations of anxiety states, neuroses, and psychoses with low serum urea nitrogen and elevated albumin were overlooked.1 A 28-chemistry Metabolic Profile was performed routinely and consecutively on admission on each of 41,145 patients from seven associated hospitals in the Birmingham area during 1968 and 1969 including Hill Crest, a psychiatric hospital. From the distributions of the serum chemistries the mode was taken as the critical point, and the central 50% of the population considered normal with each side of the curves analyzed separately. The upper 25% from the upper half was considered high, and the lower 25% from the lower half, low. Analysis was by the Chi-square test and probabilities of 0.01 or less were taken as significant. Only disease