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September 29, 1969

Effect of Cyproheptadine on Appetite and Weight Gain in Adults

Author Affiliations

From the Department of Medicine, University of California Medical Center, San Francisco.

JAMA. 1969;209(13):2054-2055. doi:10.1001/jama.1969.03160260058019

Cyproheptadine (Periactin) hydrochloride, a histamine and serotonin antagonist, was compared with placebo for effectiveness in producing appetite stimulation and weight gain in healthy, underweight, adults. Increase in appetite and weight was significantly greater statistically in those who received cyproheptadine. Drowsiness was a common transient side effect of cyproheptadine. There were no significant alterations in laboratory values following cyproheptadine administration.

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