Fourteen workers in an isopropyl alcohol packaging plant became ill after accidental exposure to carbon tetrachloride. In four, renal failure or hepatitis developed. Isopropyl alcohol potentiation of carbon tetrachloride toxicity has been shown previously only in rats. Acetone, a product of isopropyl alcohol metabolism, is a major potentiator of carbon tetrachloride toxicity. Workers had elevated levels of acetone in samples of expired alveolar gas and thus were metabolically predisposed to carbon tetrachloride injury. Stricter limits for industrial carbon tetrachloride exposure should be established where concomitant isopropyl alcohol use occurs.
(JAMA 236:1853-1856, 1976)
Folland DS, Schaffner W, Ginn HE, Crofford OB, McMurray DR. Carbon Tetrachloride Toxicity Potentiated by Isopropyl Alcohol: Investigation of an Industrial Outbreak. JAMA. 1976;236(16):1853–1856. doi:10.1001/jama.1976.03270170019018
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: