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April 30, 1973

Section 3.—Biology of Connective Tissue and the Joints

JAMA. 1973;224(Suppl_5):669-677. doi:10.1001/jama.1973.03220190009006

Composition of Connective Tissue.—  Connective tissue is the collective designation for the tissues which provide the supportive framework and protective covering of the body and its internal organs.1-5 Connective tissue includes bone, periosteum, cartilage, tendon, tendon sheath, ligament, and fascia and constitutes the major substance of the dermis, the joints, and the bursae, and the blood vessels. The connective tissues serve as conduits for the transport of essential nutrients to the organs and the collection of metabolic wastes, as well as the arena for inflammatory and immunologie reactions which protect the body from invasion by microorganisms or the influence of various other noxious agents. Connective tissue plays a major role in repairing the damage caused when there is disruption of normal structure by injury (trauma)or disease.The several varieties of connective tissue are formed by the differentiation of mesenchymal cells which