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April 30, 1973

Section 61.—Osteitis Deformans (Paget's Disease of Bone)

JAMA. 1973;224(Suppl_5):782-783. doi:10.1001/jama.1973.03220190122064

Osteitis deformans, or Paget's disease of bone (J. Paget, 1877; previously described by S. Wilks, 1869) is a chronic disorder of the adult skeleton in which the initial destruction and subsequent remodeling leads to enlargement and softening of affected bone.1 The disease has been found in approximately 1% to 3% of persons past age 45, and is most often polyostotic. Familial aggregation has been described and an autosomal dominant inheritance has been suggested. The bones most commonly affected are the pelvis, femur, skull, tibia, and vertebrae. Many patients, particularly those with monostotic disease, remain asymptomatic, but with more extensive involvement there is pain referable to the axial skeleton and hips. When the remodeling process is active, there is an increased blood flow in the bone and the overlying skin may be warm. Occasionally the excessive circulation is sufficient to contribute to the development of cardiac failure. An increase in