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November 1, 1976

Diagnosis and Follow-up of Hepatic Adenomas

JAMA. 1976;236(18):2051. doi:10.1001/jama.1976.03270190013007

To the Editor.—  Antoniades et al (234:628, 1975) recently described two simultaneous, separate hepatic adenomas in a patient taking oral contraceptives and indicated that liver scans "could be of assistance in evaluating these tumors." Ishak and Rabin1 reported finding two or more separate nodules in 22 of 75 women who had hepatic adenomas during the reproductive period. Stauffer et al2 also found multiple nodules of focal nodular hyperplasia in a woman taking oral contraceptives. Thus, the occurrence of multiple synchronous hepatic adenomas in the same patient is probably a frequent phenomenon. Contrary to what Antoniades and colleagues suggest, liver scans lack the accuracy required for the diagnosis and follow-up of these tumors. The following report illustrates the limitations of the liver scan in a patient with multiple adenomas.

Report of a Case.—  A 37-year-old woman complained of indigestion and weakness of one month's duration. She had taken oral