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November 1, 1976

Immunoblastic Lymphadenopathy

JAMA. 1976;236(18):2098. doi:10.1001/jama.1976.03270190054035

Lessons taught by a knowledgeable pathologist, whether by clinicopathologic conference or by other means, have undisputed value to clinicians. A case in point is found in a report by Kalus in a recent issue of Archives of Pathology and Laboratory Medicine (100:465-468, 1976). The subject is immunoblastic lymphadenopathy, a disease, or possibly a group of diseases, recognized only recently.

Frizzera et al1 seem to have been the first authors to give sufficient emphasis to the importance of identifying a group of lymphoproliferative diseases for what they are not, namely, Hodgkin disease or other malignant lymphomas. The authors used the term "angio-immunoblastic lymphadenopathy with dysproteinemia" and described the clinical features and microscopical characteristics in 15 patients. Usually the disease began acutely in an elderly person, with severe constitutional symptoms, generalized lymphadenopathy, hepatosplenomegaly, polyglonal hypergammaglobulinemia, and hemolytic anemia. Patients had a notable susceptibility to infections that may have been induced or