A patient had a simultaneous occurrence of an ileal and a rectal carcinoid. The ileal carcinoid, occurring in an area derived from primitive midgut, was argentaffin-positive; the rectal carcinoid, occurring in an area derived from primitive hindgut, was argentaffin-negative. To my knowledge, this is the first reported case of simultaneous ileum and rectal carcinoids; its uniqueness tends to support the concept of heterogeneity of origin of carcinoids in embryologically distinct regions.
(JAMA 236:2201-2203, 1976)
Colbert PM. Primary Carcinoids of the Ileum and Rectum: A Simultaneous Occurrence. JAMA. 1976;236(19):2201–2203. doi:10.1001/jama.1976.03270200039028
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