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November 22, 1976

Bisalbuminemia and Diabetes?

Author Affiliations

The Buffalo General Hospital, Buffalo, NY

JAMA. 1976;236(21):2393. doi:10.1001/jama.1976.03270220015015

To the Editor.—  Bisalbuminemia, a condition characterized by two albumin bands on electrophoresis of serum,1 is hereditary-transmitted. Several cases of induced bisalbuminemia have been reported.2 Despite the differences in some properties of the alloalbumin compared to normal albumin, such as binding of thyroxine, no definite pathological condition has been ascribed so far to bisalbuminemia.3In the last few years, we found three cases of bisalbuminemia of the "fast" variant among hospitalized patients. All three patients had diabetes mellitus, and a family history of diabetes was found in two of them. From the description of other cases of bisalbuminemia, we could find diabetes in four other cases.1,4,5Since the prevalence of diabetes is high in hospitalized patients, its apparent association with bisalbuminemia might be fortuitous. Association of some forms of diabetes with a genetic trait, HLA type, was described.6 In our cases, as in others,5