Twenty-five patients undergoing total hip replacement received low doses of heparin sodium. Phlebography was used for the diagnosis of deep venous thrombosis. Five thousand international units (IU) of heparin were given subcutaneously two hours preoperatively, 5,000 IU postoperatively the night of surgery, and every 12 hours for the next seven to ten days. Venous thrombosis developed in seven of 25 patients. Pulmonary embolism occurred in six patients. Until further studies are forthcoming, the utmost caution is urged in the use of low doses of heparin as a prophylactic agent after total hip reconstruction.
Evarts CM, Alfidi RJ. Thromboembolism After Total Hip ReconstructionFailure of Low Doses of Heparin in Prevention. JAMA. 1973;225(5):515–516. doi:10.1001/jama.1973.03220320045013
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