Of 298 outpatients receiving clindamycin for a variety of indications, diarrhea developed in ten (3.4%); none were diagnosed as having pseudomembranous colitis. This is well within the range of relative frequencies of diarrhea development (0% to 22.2%) reported in 45 previous studies. Reliance solely on computer-recorded instances of diarrhea yielded a substantial underestimate of diarrhea occurrence, but the rate was still significantly higher (P <.05) in clindamycin users than in nonusers.
(JAMA 236:2498-2500, 1976)
Friedman GD, Gérard MJ, Ury HK. Clindamycin and Diarrhea. JAMA. 1976;236(22):2498–2500. doi:10.1001/jama.1976.03270230020020
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