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December 1, 1969

Etiologic Models of Rheumatoid Arthritis

JAMA. 1969;210(9):1754. doi:10.1001/jama.1969.03160350066015

Experimental models of arthritis induced in animals provide a useful means toward the understanding of rheumatoid disease in man. Of interest are the recently reported adjuvant-induced arthritis in rats, the peroxidase provoked arthritis in rabbits, and the arthritis produced in mice injected with synovial material from inflamed human joints of rheumatoid arthritis patients.

Arthritis and other lesions affecting the periarticular connective tissues, and occasionally the genitalia and the eye, have been induced by Pearson and co-workers1 in inbred Lewis rats 10 to 15 days after an intradermal injection of Freund's adjuvant. The syndrome, which was transferable to normal recipients with sensitized lymph node cells, could be prevented by thoracic duct drainage. Attributable to interaction of immunologically competent cells with components of the tubercle bacillus in the adjuvant, the lesions manifested histologic features resembling those found in rheumatoid arthritis.

Graham and Shannon2 produced a similar model of immunologically mediated arthritis