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In answer to Dr Handsfield's question, 15 of the 161 comparisons involved identical positive cultures from both sites.
The reason for the high rate of isolation of Staphylococcus epidermidis from catheter-drawn cultures remains an important question. As stated in the article, the significance of an isolated culture revealing this organism is unknown. Providing one is willing to withhold making any conclusion regarding Staphylococcus epidermidis, the method is valid.
Tonnesen A, LOCKWOOD WR. Blood Cultures Drawn Through Catheters-Reply. JAMA. 1976;236(26):2944. doi:10.1001/jama.1976.03270270006016
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