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January 3, 1977

Mannitol and Amphotericin B-Reply

JAMA. 1977;237(1):27. doi:10.1001/jama.1977.03270280029016

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In Reply.—  We would like to thank Dr Jotkowitz for his interest. The patient's weight was 70 kg. As stated in the article, 25 gm mannitol was added to 17.5 mg amphotericin B and both medications in solution were infused simultaneously. Specifically, amphotericin B powder was diluted with the manufacturer's supplied diluent to a concentration of 5 mg/ml. Then 3.5 ml of this amphotericin solution was added to 125 ml of a 20% mannitol solution, which was then diluted with 5% dextrose in water to 1,000 ml prior to infusion. The final amphotericin B concentration was 0.0175 mg/ml and the mannitol was a 2.5% solution.