Three cases of acute psychotic illness following sudden withdrawal from high daily doses of benzodiazepines were associated with agitation and confusion. Disorientation was prominent in two of the patients. None of the patients had had previous psychotic episodes. The condition of all patients was reversed dramatically with hypnotic drugs. Gradual withdrawal was successfully accomplished without relapse, with a follow-up of as much as one year. To our knowledge, this is the first such series in the literature.
(JAMA 237:36-38, 1977)
Preskorn SH, Denner LJ. Benzodiazepines and Withdrawal PsychosisReport of Three Cases. JAMA. 1977;237(1):36–38. doi:10.1001/jama.1977.03270280038018
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