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January 10, 1977

Burkitt Lymphoma During Pregnancy With Bilateral Breast Involvement

JAMA. 1977;237(2):151. doi:10.1001/jama.1977.03270290051027

BREAST involvement by Burkitt lymphoma is rare but occurs most frequently during pregnancy. In this case, the patient had bilateral breast involvement in the first trimester of pregnancy. Bone marrow and peripheral blood involvement were also present. Hypercalcemia accompanied by elevated parathyroid hormone levels occurred with widespread organ involvement, including CNS disease.

Report of a Case  In a 42-year-old white woman (gravida 10, para 6, abortus 3), tenderness and multiple nodules of both breasts developed during the third month of pregnancy. Antibiotics were prescribed without resolution, and the patient was referred for examination. Physical examination showed a 4-cm, lobular mass in the right axilla. Her breasts were large, pendulous, erythematous, and extremely tender, with extensive superficial venous distention but without specific nodules. Both the liver and spleen were enlarged, and multiple nodules were palpated in the anterior abdominal wall. The uterus was four months gestational size. A mass was palpated