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January 24, 1977

Gout and Uric Acid Metabolism

JAMA. 1977;237(4):387. doi:10.1001/jama.1977.03270310073014

Gout, at a practical level of pathogenesis, diagnosis, and treatment, has yielded most of its secrets to modern medical science. These aspects are covered succinctly in brief published reviews in journals and in standard textbooks. Therefore, this book by two longtime students of gout and urate metabolism will be of interest primarily to rheumatologists and investigators in the field. Dr Jay Seegmiller, a renowned investigator of urate metabolism, joins Drs Talbott and Yü by contributing one chapter on purine metabolism.

The contents of the book include a charming historical review of gout, presumably written by Dr Talbott. Three chapters on purine metabolism, physiology of urate metabolism, and renal mechanisms in uric acid excretion constitute the tough scientific core of the book. Although these chapters are well written, with minimal overlap and redundancy, they are hard going for the general reader. Since the information is complex, it simply does not lend