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December 29, 1969

Sulfonamides and Aspergillosis

Author Affiliations

New England Deaconess Hospital Boston
Emory University Hospital Atlanta

JAMA. 1969;210(13):2398. doi:10.1001/jama.1969.03160390060022

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To the Editor:—  In The Journal (209:1191, 1969) a case of pulmonary aspergillosis is reported. A number of articles on systemic aspergillosis cite the various types of therapy during the past few years. None has mentioned the use of sulfonamide drugs.The studies and observations, made in the bacteriology laboratory of the New England Baptist Hospital, on a strain of Aspergillus isolated from a case of pulmonary aspergillosis noted that the organism was very sensitive to sulfonamides. A number of strains of Aspergillus were obtained and most of them were found to be sensitive to sulfonamides. We had hoped to test the clinical success of this therapy but have not had any cases of aspergillosis for treatment.We should like to report this experience in the hope that this type of therapy might be found useful. We realize that sensitivities on an agar plate might not reflect in vivo