Serial measurements of serum methyprylon concentration were made in the case of a 14-year-old girl who ingested an overdose of the drug. Our data indicate that, in the presence of high plasma levels of the drug, much longer half-lives than the usually reported four hours may be observed. It is postulated that saturation kinetics may be a possible mechanism for this observation.
The striking clinical improvement after six hours of hemodialysis demonstrated the efficacy of this mode of treatment in our patient.
(JAMA 237:470-471, 1977)
Pancorbo AS, Palagi PA, Piecoro JJ, Wilson HD. Hemodialysis in Methyprylon OverdoseSome Pharmacokinetic Considerations. JAMA. 1977;237(5):470–471. doi:10.1001/jama.1977.03270320048022
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