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January 31, 1977

Hemodialysis in Methyprylon OverdoseSome Pharmacokinetic Considerations

JAMA. 1977;237(5):470-471. doi:10.1001/jama.1977.03270320048022

Serial measurements of serum methyprylon concentration were made in the case of a 14-year-old girl who ingested an overdose of the drug. Our data indicate that, in the presence of high plasma levels of the drug, much longer half-lives than the usually reported four hours may be observed. It is postulated that saturation kinetics may be a possible mechanism for this observation.

The striking clinical improvement after six hours of hemodialysis demonstrated the efficacy of this mode of treatment in our patient.

(JAMA 237:470-471, 1977)