Amikacin sulfate was administered to 18 patients for the treatment of 19 severe infections. Seventeen infections were caused by gentamicin-resistant Gram-negative bacilli, and 13 patients were bacteremic. Bacteriologic cure was attained in all but one instance, and effective serum, bile, and pleural fluid drug levels were demonstrated. Drug-related fever occurred in one patient, and another experienced a maculopapular rash and monilial intertrigo. In three patients, reversible renal toxicity developed, but none had clinical evidence of ototoxicity. Amikacin sulfate in a dose of 15 mg/kg/day is an effective antibiotic for the treatment of serious Gram-negative infections, particularly those due to gentamicin-resistant organisms.
(JAMA 237:562-564, 1977)
Pollock AA, Berger SA, Richmond AS, Simberkoff MS, Rahal JJ. Amikacin Therapy for Serious Gram-Negative Infection. JAMA. 1977;237(6):562–564. doi:10.1001/jama.1977.03270330052020
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