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Article
February 14, 1977

Penicillium Granuloma of the Lung Presenting as a Solitary Pulmonary Nodule

JAMA. 1977;237(7):671. doi:10.1001/jama.1977.03270340057021
Abstract

PENICILLIUM infections are seldom of clinical importance, but there have been reports in the literature of Penicillium infections of the ear, feet, urinary bladder, and lung.1Penicillium is classified under the class Ascomycetes, with the best known form being Penicillium notatum, from which penicillin is obtained.

We report a pure Penicillium infection of the lung that presented as a coin lesion.

Report of a Case  A 34-year-old man was referred for evaluation of a solitary pulmonary nodule in the posterior segment of the right upper lobe of the lung. The patient was entirely asymptomatic, and the lesion was found on routine chest roentgenogram (Figure). He gave a history of smoking one pack of cigarettes per day for 20 years. He was employed as a machine operator for a rail-road.Serial roentgenograms taken over a two-month period showed no change in the size of the lesion. No calcium was noted

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