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February 14, 1977

Cryptococcal Cellulitis

JAMA. 1977;237(7):672-673. doi:10.1001/jama.1977.03270340058022

INFECTION with Cryptococcus neoformans, an encapsulated yeast-like fungus, is most often a subacute to chronic process that is thought to be acquired by invasion of the respiratory tract from which the organisms may spread hematogenously. The incidence of cutaneous involvement in cryptococcosis is approximately 10%.1 Although there is no specific cutaneous manifestation of cryptococcal infection, a number of lesions have been reported with sufficient frequency that they may be considered to be characteristic of this infection. Traditionally, cellulitis has not been among these. This communication reports a compromised patient who had cellulitis that proved to be due to Cryptococcus neoformans.

Report of a Case  A 62-year-old woman receiving prednisone (40 mg/day) and azathioprine (100 mg/day) for chronic, active hepatitis was hospitalized because of a two-week history of back and leg pain and increasing weak-ness.On admission she was lethargic but oriented. Vital signs were normal except for an oral