Recognizing that most patients with moderate or severe elevation of diastolic blood pressure require a double or triple antihypertensive drug regimen and, also, that the presence of hypertensive complications further modifies drug selection, it is readily apparent that the therapist must be intimately familiar with the clinical pharmacology of these drugs, if he is to achieve the optimum result. The purpose of this communication is to review mechanisms of action and hemodynamic effects of the commonly employed antihypertensive drugs.
Orally Given Diuretics
Of the various groups of antihypertensive drugs, the diuretics for oral administration have the greatest overall clinical usefulness. Their therapeutic advantages may be summarized as follows: (1) they lower blood pressures with the patient in both the supine and erect positions, (2) the overall incidence of side reactions accompanying their usage is low, (3) their antihypertensive effects are maintained despite prolonged administration, and (4) the orally given diuretics
Brest AN, Onesti G, Swartz C, Seller R, Kim KE, Chinitz J. Mechanisms of Antihypertensive Drug Therapy. JAMA. 1970;211(3):480–484. doi:10.1001/jama.1970.03170030072011
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